Dublin Office: +353 1 460 7600 | Cork Office: +353 21 233 9410
Dublin Office: +353 1 460 7600 | Cork Office: +353 21 233 9410
NexSus provides flexible, custom Single Use assemblies designed around the specific requirements of your application, workflow and production environment.
No two manufacturing processes are exactly the same. NexSus provides flexible, custom Single Use assemblies designed around the specific requirements of your application, workflow and production environment.
Rather than asking customers to adapt their process to a standard solution, we work collaboratively with you to understand how fluids move through your operation, the conditions each component must withstand and the outcomes your system needs to deliver. From straightforward tubing configurations to more complex integrated fluid paths, every assembly is developed to support safe, efficient and reliable processing.
Our approach is centred on flexibility. NexSus combines access to high-quality Single Use components with local technical expertise, allowing us to create assemblies tailored to your operational requirements.
We consider factors such as fluid compatibility, connection points, flow rates, sterilisation requirements, operating conditions and scalability. This helps us develop practical solutions that integrate with your existing equipment and processes while reducing unnecessary complexity.
Custom assemblies can support new manufacturing projects, process optimisation, scale-up activities or the replacement of existing systems. As your requirements evolve, our team can work with you to adapt and refine the solution.
Custom bottle-based fluid paths configured around PharmaTainer and other compatible rigid-container platforms.
NexSus supports the design and supply of bottle assemblies tailored to the process, combining rigid containers with tubing, closures, filters, connectors, dip tubes, sampling points and other required components. Configurations can support development, upstream, downstream, formulation and final-fill applications.
Typical applications:
Seed-train media transfer; cell-expansion sampling and feed addition; clarified-harvest hold; chromatography buffer transfer and fraction collection; viral-inactivation holds; UF/DF collection; formulation sampling; transfer to aseptic filling.
Flexible single-use bag assemblies configured for process holds, transfer, sampling and fluid management applications.
NexSus provides bag-based assembly solutions built around the required process volume, film platform, port configuration, tubing, connectors and sampling or transfer requirements. These assemblies can be tailored for use throughout upstream, downstream, formulation and final-fill operations.
Typical applications:
Buffer and media preparation and hold; inoculum and feed transfer; aseptic sampling; waste collection; intermediate and buffer hold; chromatography pools; UF/DF pools; formulation hold; bulk drug-product hold and transfer; filling-assembly surge bags.
Tailored transfer assemblies for reliable movement of critical fluids between containers, process equipment and manufacturing steps.
NexSus helps customers configure single-use transfer assemblies around the fluid, process equipment, connection points and operating conditions of the application. Solutions can range from simple tubing sets to integrated transfer paths with connectors, filters, sensors, manifolds and container interfaces.
Typical applications:
Shake-flask to bioreactor transfer; harvest transfer to clarification; clarified-harvest transfer to chromatography; buffer addition; viral-inactivation transfer; UF/DF buffer exchange; formulation excipient addition; sterile filtration.
Single-use filtration assemblies configured for consistent fluid transfer, sterilising filtration and integrity-testing workflows.
NexSus supports filtration assemblies that combine the required filter, tubing, connectors and process interfaces into a ready-to-use fluid path. Configurations can be designed for buffer and media filtration, sterile product filtration and pre-use post-sterilisation integrity testing.
Typical applications:
Buffer and media filtration; upstream bioburden reduction; clarified-transfer filtration; sterile product filtration; bulk-drug-substance filtration before filling; PUPSIT and offline integrity-testing arrangements.
Custom assemblies built around centrifuge tubes, shaker flasks, glass bottles and other specialist rigid containers.
NexSus supports specialised bottle and vessel assemblies where a standard PharmaTainer format is not the best fit. Solutions can be configured around centrifuge tubes, shaker flasks, glass bottles and other compatible containers with tailored closures, tubing, filters and sampling components.
Typical applications:
Inoculum sampling; media lysis buffer; cell expansion; inoculation expansion; scale-down studies; TFF permeate hold; buffer exchange and sampling; polishing hold; UF/DF sampling; fraction collection; viral-hold sampling; formulation aliquots; retention storage; sterility sampling.
Single-use mixing assemblies configured for powder and liquid mixing across development and production scales.
NexSus provides access to mixing assemblies that combine the required vessel, mixing platform, tubing, ports and transfer connections. Solutions can be configured around top-mounted or bottom-mounted mixing approaches and integrated into the wider fluid path.
Typical applications:
Media preparation; buffer preparation; formulation; powder dissolution; liquid blending; process-development and production-scale mixing.
Custom final-filling fluid paths designed to support controlled, repeatable transfer into bottles, bags, vials and other receiving containers.
NexSus supports final-filling assemblies configured around the product, fill volume, container format, connection strategy and required level of process closure. Assemblies can integrate tubing, manifolds, filling needles, filters, connectors and intermediate hold components.
Typical applications:
Bulk drug-product transfer; sterile filtration into filling isolators; bottle and bag filling; multi-container filling; controlled aliquotation; fill-finish surge and hold applications.
Configurable bag-based fluid management solutions for storage, hold, transfer, mixing and filling applications.
NexSus combines flexible bag platforms with tubing, ports, connectors, filters and sampling or transfer components to create application-specific bag solutions. Systems can be configured as simple process holds or as part of a wider fluid path.
Typical applications:
Media and buffer hold; feed transfer; waste collection; intermediate pools; formulation hold; bulk drug-product hold; filling surge; final transfer.
Configured centrifuge-tube assemblies for closed sampling, transfer, hold and small-volume processing.
NexSus supports centrifuge-tube sets that combine suitable closure systems, tubing and connection components for controlled small-volume fluid handling. These assemblies can be used in process development, sampling and advanced-therapy workflows.
Typical applications:
Closed sampling; small-volume aliquots; process-development studies; cell and gene therapy; media and buffer handling; sample retention.
Custom flask assemblies for inoculum, cell expansion, sampling and laboratory-to-process transfer.
NexSus supports flask assemblies configured with appropriate closures, tubing, filters and connectors for cell-culture, inoculum and process-development applications. Assemblies can help bridge small-scale operations with larger upstream systems.
Typical applications:
Inoculum expansion; shake-flask transfer; cell-culture sampling; media addition; seed-train transfer; process development.
Multi-line manifold assemblies for distributing, combining or collecting fluids across multiple process connections.
NexSus supports manifold assemblies that consolidate multiple fluid paths into a controlled single-use configuration. Manifolds can be designed for distribution, collection, filling, sampling or transfer and configured with the required tubing, valves, connectors and container interfaces.
Typical applications:
Media and buffer distribution; multi-container filling; sample collection; pooled fraction collection; parallel transfer; process-scale aliquotation.
Controlled aliquotation assemblies for splitting process fluids into multiple defined receiving containers.
NexSus supports aliquotation systems configured to divide a bulk process fluid into smaller containers while maintaining a controlled fluid path. Assemblies can be designed around required fill volumes, container formats, tubing, valves, manifolds and connection methods.
Typical applications:
Process sampling; stability samples; small-volume filling; formulation aliquots; retention samples; intermediate distribution.
Preconfigured sampling kits for controlled collection of representative process samples.
NexSus supports sampling kits tailored to the sampling point, sample volume, container format and connection method. Kits can integrate tubing, sterile connectors, clamps, valves and sample containers to support closed or controlled sampling workflows.
Typical applications:
Upstream process sampling; downstream sampling; formulation samples; in-process control; stability samples; QC sample collection.
Multi-container sampling assemblies designed to collect several process samples through a controlled single-use fluid path.
NexSus supports simultaneous-sampling configurations where multiple samples must be collected efficiently and consistently from a single process point. Assemblies can be tailored around the required number of samples, container type, tubing arrangement and connection strategy.
Typical applications:
Parallel in-process sampling; stability sample collection; multi-timepoint sampling; QC sample collection; small-volume aliquotation.
Whether you’re looking for technical guidance, product information or support with your Single Use Systems requirements, our team is here to help.
Speak to a specialist or request a consultation
+353 1 460 7600
customerservice@lennox.ie
